{"type":"standard","title":"Igmesine","displaytitle":"Igmesine","namespace":{"id":0,"text":""},"wikibase_item":"Q5992117","titles":{"canonical":"Igmesine","normalized":"Igmesine","display":"Igmesine"},"pageid":23938639,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Igmesine.svg/330px-Igmesine.svg.png","width":320,"height":158},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Igmesine.svg/512px-Igmesine.svg.png","width":512,"height":253},"lang":"en","dir":"ltr","revision":"1252446062","tid":"c4bc87f5-8fa0-11ef-ac19-7a13d4e9dd61","timestamp":"2024-10-21T11:36:53Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Igmesine","revisions":"https://en.wikipedia.org/wiki/Igmesine?action=history","edit":"https://en.wikipedia.org/wiki/Igmesine?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Igmesine"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Igmesine","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Igmesine","edit":"https://en.m.wikipedia.org/wiki/Igmesine?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Igmesine"}},"extract":"Igmesine (JO-1,784) is a sigma receptor agonist (IC50 = 39Â nM (rat brain)). It has neuroprotective and antidepressant-like effects in animal studies, as well as nootropic effects in models of age-related cognitive decline. In two phase II clinical trials, igmesine was found to be effective in the treatment of depression and was as active as the comparator fluoxetine. However, in a large phase III clinical trial, igmesine failed to show significant effectiveness for depression. The drug has not been developed further.","extract_html":"
Igmesine (JO-1,784) is a sigma receptor agonist (IC50 = 39Â nM (rat brain)). It has neuroprotective and antidepressant-like effects in animal studies, as well as nootropic effects in models of age-related cognitive decline. In two phase II clinical trials, igmesine was found to be effective in the treatment of depression and was as active as the comparator fluoxetine. However, in a large phase III clinical trial, igmesine failed to show significant effectiveness for depression. The drug has not been developed further.
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{"slip": { "id": 30, "advice": "When in doubt, just take the next small step."}}
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{"type":"standard","title":"Sion Mills","displaytitle":"Sion Mills","namespace":{"id":0,"text":""},"wikibase_item":"Q576454","titles":{"canonical":"Sion_Mills","normalized":"Sion Mills","display":"Sion Mills"},"pageid":4049184,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Herdman%27s_Mill%2C_Sion_Mills%2C_County_Tyrone_-_geograph.org.uk_-_1076496.jpg/330px-Herdman%27s_Mill%2C_Sion_Mills%2C_County_Tyrone_-_geograph.org.uk_-_1076496.jpg","width":320,"height":189},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/a/a4/Herdman%27s_Mill%2C_Sion_Mills%2C_County_Tyrone_-_geograph.org.uk_-_1076496.jpg","width":640,"height":377},"lang":"en","dir":"ltr","revision":"1281446373","tid":"b2af2afe-0588-11f0-96cb-65438f26de40","timestamp":"2025-03-20T12:41:52Z","description":"Village in County Tyrone, Northern Ireland","description_source":"local","coordinates":{"lat":54.78535,"lon":-7.47427},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Sion_Mills","revisions":"https://en.wikipedia.org/wiki/Sion_Mills?action=history","edit":"https://en.wikipedia.org/wiki/Sion_Mills?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Sion_Mills"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Sion_Mills","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Sion_Mills","edit":"https://en.m.wikipedia.org/wiki/Sion_Mills?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Sion_Mills"}},"extract":"Sion Mills is a village to the south of Strabane in County Tyrone, Northern Ireland, on the River Mourne. In the 2001 Census it had a population of 2,050 people. It is a tree-lined industrial village and designated conservation area, particularly rich in architectural heritage.","extract_html":"
Sion Mills is a village to the south of Strabane in County Tyrone, Northern Ireland, on the River Mourne. In the 2001 Census it had a population of 2,050 people. It is a tree-lined industrial village and designated conservation area, particularly rich in architectural heritage.
"}{"type":"standard","title":"Friedrich Ernst Fesca","displaytitle":"Friedrich Ernst Fesca","namespace":{"id":0,"text":""},"wikibase_item":"Q325731","titles":{"canonical":"Friedrich_Ernst_Fesca","normalized":"Friedrich Ernst Fesca","display":"Friedrich Ernst Fesca"},"pageid":2674552,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/3/39/Friedrich_Ernst_Fesca.jpg/330px-Friedrich_Ernst_Fesca.jpg","width":320,"height":402},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/3/39/Friedrich_Ernst_Fesca.jpg","width":1440,"height":1810},"lang":"en","dir":"ltr","revision":"1263005021","tid":"16e0b5b6-b9ce-11ef-bfde-dc592dd52cd4","timestamp":"2024-12-14T03:47:07Z","description":"German violinist and composer (1789–1826)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Friedrich_Ernst_Fesca","revisions":"https://en.wikipedia.org/wiki/Friedrich_Ernst_Fesca?action=history","edit":"https://en.wikipedia.org/wiki/Friedrich_Ernst_Fesca?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Friedrich_Ernst_Fesca"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Friedrich_Ernst_Fesca","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Friedrich_Ernst_Fesca","edit":"https://en.m.wikipedia.org/wiki/Frie